| 1950/51 | 19/08/1950 | Leyton Orient | Football League 3 South | Home Park | Match Programme | Argyle 2 Leyton Orient 1 |
| 1950/51 | 24/08/1950 | Walsall | Football League 3 South | Fellows Park | Match Programme | Walsall 1 Argyle 1 |
| 1950/51 | 26/08/1950 | Ipswich Town | Football League 3 South | Portman Road | Match Programme | Ipswich Town 2 Argyle 0 |
| 1950/51 | 30/08/1950 | Walsall | Football League 3 South | Home Park | Match Programme | Argyle 1 Walsall 1 |
| 1950/51 | 02/09/1950 | Port Vale | Football League 3 South | Home Park | Match Programme | Argyle 1 Port Vale 0 |
| 1950/51 | 06/09/1950 | Nottingham Forest | Football League 3 South | City Ground | Match Programme | Nottingham Forest 4 Argyle 1 |
| 1950/51 | 09/09/1950 | Reading | Football League 3 South | Home Park | Match Programme | Argyle 2 Reading 0 |
| 1950/51 | 13/09/1950 | Nottingham Forest | Football League 3 South | Home Park | Match Programme | Argyle 0 Nottingham Forest 2 |
| 1950/51 | 16/09/1950 | Southend United | Football League 3 South | Roots Hall | Match Programme | Southend United 1 Argyle 0 |
| 1950/51 | 23/09/1950 | Exeter City | Football League 3 South | Home Park | Match Programme | Argyle 0 Exeter City 1 |
| 1950/51 | 30/09/1950 | Bournemouth and Boscombe Athletic | Football League 3 South | Dean Court | Match Programme | Bournemouth and Boscombe Athletic 0 Argyle 2 |
| 1950/51 | 07/10/1950 | Torquay United | Football League 3 South | Plainmoor | Match Programme | Torquay United 1 Argyle 3 |
| 1950/51 | 14/10/1950 | Aldershot | Football League 3 South | Home Park | Match Programme | Argyle 5 Aldershot 1 |
| 1950/51 | 21/10/1950 | Swindon Town | Football League 3 South | County Ground | Match Programme | Swindon Town 1 Argyle 3 |
| 1950/51 | 28/10/1950 | Colchester United | Football League 3 South | Home Park | Match Programme | Argyle 7 Colchester United |
| 1950/51 | 04/11/1950 | Bristol Rovers | Football League 3 South | Eastville | Match Programme | Bristol Rovers 3 Argyle 1 |
| 1950/51 | 11/11/1950 | Crystal Palace | Football League 3 South | Home Park | Match Programme | Argyle 4 Crystal Palace 0 |
| 1950/51 | 18/11/1950 | Brighton and Hove Albion | Football League 3 South | Goldstone Ground | Match Programme | Brighton and Hove Albion 0 Argyle 6 |
| 1950/51 | 25/11/1950 | Gainsbrough Trinity | FA Cup | Northolme | Match Programme | Gainsbrough Trinity 0 Argyle 3 |
| 1950/51 | 02/12/1950 | Norwich City | Football League 3 South | Carrow Road | Match Programme | Norwich City 1 Argyle 0 |
| 1950/51 | 09/12/1950 | Crewe Alexandra | FA Cup | Gresty Road | Match Programme | Crewe Alexandra 2 Argyle 2 |
| 1950/51 | 13/12/1950 | Crewe Alexandra | FA Cup | Home Park | Match Programme | Argyle 3 Crewe Alexandra 0 |
| 1950/51 | 23/12/1950 | Ipswich Town | Football League 3 South | Home Park | Match Programme | Argyle 2 Ipswich Town 1 |
| 1950/51 | 25/12/1950 | Bristol City | Football League 3 South | Ashton Gate | Match Programme | Bristol City 1 Argyle 0 |
| 1950/51 | 26/12/1950 | Bristol City | Football League 3 South | Home Park | Match Programme | Argyle 2 Bristol City 0 |
| 1950/51 | 30/12/1950 | Port Vale | Football League 3 South | Vale Park | Match Programme | Port Vale 2 Argyle 1 |
| 1950/51 | 06/01/1951 | Wolverhampton Wanderers | FA Cup | Home Park | Match Programme | Argyle 1 Wolverhampton Wanderers 2 |
| 1950/51 | 10/01/1951 | Watford | Football League 3 South | Home Park | Match Programme | Argyle 3 Watford 1 |
| 1950/51 | 13/01/1951 | Reading | Football League 3 South | Elm Park | Match Programme | Reading 4 Argyle 0 |
| 1950/51 | 20/01/1951 | Southend United | Football League 3 South | Home Park | Match Programme | Argyle 2 Southend United 0 |
| 1950/51 | 27/01/1951 | Watford | Football League 3 South | Vicarage Road | Match Programme | Watford 1 Argyle 1 |
| 1950/51 | 03/02/1951 | Exeter City | Football League 3 South | St James’ Park | Match Programme | Exeter City 3 Argyle 2 |
| 1950/51 | 10/02/1951 | Newport County | Football League 3 South | Home Park | Match Programme | Argyle 3 Watford 1 |
| 1950/51 | 17/02/1951 | Bournemouth and Boscombe Athletic | Football League 3 South | Home Park | Match Programme | Argyle 3 Bounemouth and Boscombe Athletic 1 |
| 1950/51 | 24/02/1951 | Torquay United | Football League 3 South | Home Park | Match Programme | Argyle 0 Torquay United 0 |
| 1950/51 | 03/03/1951 | Aldershot | Football League 3 South | Recreation Ground | Match Programme | Aldershot 2 Argyle 2 |
| 1950/51 | 10/03/1951 | Swindon Town | Football League 3 South | Home Park | Match Programme | Argyle 5 Swindon Town 1 |
| 1950/51 | 17/03/1951 | Colchester United | Football League 3 South | Layer Road | Match Programme | Colchester United 3 Argyle 0 |
| 1950/51 | 23/03/1951 | Millwall | Football League 3 South | The Den | Match Programme | Millwall 2 Argyle 2 |
| 1950/51 | 24/03/1951 | Bristol Rovers | Football League 3 South | Home Park | Match Programme | Argyle 0 Bristol Rovers 0 |
| 1950/51 | 26/03/1951 | Millwall | Football League 3 South | Home Park | Match Programme | Argyle 2 Millwall 2 |
| 1950/51 | 31/03/1951 | Crystal Palace | Football League 3 South | Selhurst Park | Match Programme | Crystal Palace 0 Argyle 1 |
| 1950/51 | 07/04/1951 | Brighton and Hove Albion | Football League 3 South | Home Park | Match Programme | Argyle 3 Brighton and Hove Albion 3 |
| 1950/51 | 09/04/1951 | Northampton | Football League 3 South | Home Park | Match Programme | Argyle 4 Northampton Town 1 |
| 1950/51 | 14/04/1951 | Newport County | Football League 3 South | Somerton Park | Match Programme | Newport County 2 Argyle 0 |
| 1950/51 | 18/04/1951 | Gillingham | Football League 3 South | Home Park | Match Programme | Argyle 2 Gillingham 0 |
| 1950/51 | 26/04/1951 | Leyton Orient | Football League 3 South | Brisbaine Road | Match Programme | Leyton Orient 1 Argyle 2 (Played 26-04-1951) |
| 1950/51 | 28/04/1951 | Northampton Town | Football League 3 South | County Ground | Match Programme | Northampton Town 1 Argyle 3 |
| 1950/51 | 05/05/1951 | Gillingham | Football League 3 South | Priestfield | Match Programme | Gillingham 1 Argyle 2 |
